標題: Centella asiatica Attenuates Diabetes Induced Hippocampal Changes in Experimental Diabetic Rats
作者: Giribabu, Nelli
Srinivasarao, Nelli
Rekha, Somesula Swapna
Muniandy, Sekaran
Salleh, Naguib
材料科學與工程學系
Department of Materials Science and Engineering
公開日期: 2014
摘要: Diabetes mellitus has been reported to affect functions of the hippocampus. We hypothesized that Centella asiatica, a herb traditionally being used to improve memory, prevents diabetes-related hippocampal dysfunction. Therefore, the aim of this study was to investigate the protective role of C. asiatica on the hippocampus in diabetes. Methods. Streptozotocin-(STZ-) induced adult male diabetic rats received 100 and 200 mg/kg/day body weight (b.w) C. asiatica leaf aqueous extract for four consecutive weeks. Following sacrifice, hippocampus was removed and hippocampal tissue homogenates were analyzed for Na+/K+-, Ca2+- and Mg2+-ATPases activity levels. Levels of the markers of inflammation (tumor necrosis factor, TNF-alpha; interleukin, IL-6; and interleukin, IL-1 beta) and oxidative stress (lipid peroxidation product: LPO, superoxide dismutase: SOD, catalase: CAT, and glutathione peroxidase: GPx) were determined. The hippocampal sections were visualized for histopathological changes. Results. Administration of C. asiatica leaf aqueous extract to diabetic rats maintained near normal ATPases activity levels and prevents the increase in the levels of inflammatory and oxidative stress markers in the hippocampus. Lesser signs of histopathological changes were observed in the hippocampus of C. asiatica leaf aqueous extract treated diabetic rats. Conclusions. C. asiatica leaf protects the hippocampus against diabetes-induced dysfunction which could help to preserve memory in this condition.
URI: http://hdl.handle.net/11536/25114
http://dx.doi.org/10.1155/2014/592062
ISSN: 1741-427X
DOI: 10.1155/2014/592062
期刊: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
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