標題: Effectiveness of holographic optical element module sensor in measuring blood prothrombin time
作者: Lin, Yu-Cheng
Yen, Shih-Chieh
Cheng, Stone
Huang, Tony
機械工程學系
Department of Mechanical Engineering
關鍵字: blood coagulation;prothrombin time;optical biosensors;seesaw actuator
公開日期: 1-Jul-2014
摘要: A small-form-factor holographic optical element (HOE) module, which was mounted on a dual-stage seesaw actuator, was utilized to evaluate blood coagulation in real time. The method involved assessing the decrease in transmitted light of the blood sample surface when the clotting is formed. The prothrombin time (PT) was measured by illumining and focusing a 635 nm laser beam onto the sample. As the fibrinogen turned into non-solute fibrin, the transmitted efficiency and total intensity of the reflected light from the reflector changed. A low-pass filter suppressed the noise in the coagulation-related transient response to yield accurate signals. Finally, the PT measurements were compared to those made classically using other optical sensors.
URI: http://dx.doi.org/10.1088/0957-0233/25/7/075701
http://hdl.handle.net/11536/24916
ISSN: 0957-0233
DOI: 10.1088/0957-0233/25/7/075701
期刊: MEASUREMENT SCIENCE & TECHNOLOGY
Volume: 25
Issue: 7
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