標題: Increased risk of major depression subsequent to a first-attack and non-infection caused urticaria in adolescence: a nationwide population-based study
作者: Kuo, Chia-Lun
Chen, Chi-Yen
Huang, Hui-Ling
Chen, Wen-Liang
Lee, Hua-Chin
Chang, Chih-Yu
Chou, Chu-Chung
Ho, Shinn-Ying
Wu, Han-Ping
Lin, Yan-Ren
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
關鍵字: Non-infection caused urticaria;Major depression;Adolescent;Pediatric;Hazard ratio
公開日期: 11-七月-2014
摘要: Background: Non-infection caused urticaria is a common ailment in adolescents. Its symptoms (e.g., unusual rash appearance, limitation of daily activities, and recurrent itching) may contribute to the development of depressive stress in adolescents; the potential link has not been well studied. This study aimed to investigate the risk of major depression after a first-attack and non-infection caused urticaria. Methods: This study used the Taiwan Longitudinal Health Insurance Database. A total of 5,755 adolescents hospitalized for a first-attack and non-infection caused urticaria from 2005 to 2009 were recruited as the study group, together with 17,265 matched non-urticarial enrollees who comprised the control group. Patients who had any history of urticaria or depression prior to the evaluation period were excluded. Each patient was followed for one year to identify the occurrence of depression. Cox proportional hazards models were generated to compute the risk of major depression, adjusting for the subjects\' sociodemographic characteristics. Depression-free survival curves were also analyzed. Results: Thirty-four (0.6%) adolescents with non-infection caused urticaria and 59 (0.3%) non-urticarial control subjects suffered a new-onset episode of major depression during the study period. The stratified Cox proportional analysis showed that the crude hazard ratio (HR) of depression among adolescents with urticaria was 1.73 times (95% CI, 1.13-2.64) than that of the control subjects without urticaria. Moreover, the HR were higher in physical (HR: 3.39, 95% CI 2.77-11.52) and allergy chronic urticaria (HR: 2.43, 95% CI 3.18-9.78). Conclusion: Individuals who have a non-infection caused urticaria during adolescence are at a higher risk of developing major depression.
URI: http://dx.doi.org/10.1186/1471-2431-14-181
http://hdl.handle.net/11536/24880
ISSN: 1471-2431
DOI: 10.1186/1471-2431-14-181
期刊: BMC PEDIATRICS
Volume: 14
Issue: 
結束頁: 
顯示於類別:期刊論文


文件中的檔案:

  1. 000339210800001.pdf