標題: Effect of Statin Therapy on Mortality in Patients With Infective Endocarditis
作者: Yang, Ten-Fang
Chu, Hsi
Ou, Shuo-Ming
Li, Szu-Yuan
Chen, Yung-Tai
Shih, Chia-Jen
Tsai, Lung-Wen
生物資訊及系統生物研究所
Institude of Bioinformatics and Systems Biology
公開日期: 1-七月-2014
摘要: The aim of our study was to determine whether pre-emptive statin therapy was associated with improved outcome of infective endocarditis (IE). We conducted a nationwide, population-based, propensity score-matched cohort study with the Taiwan\'s National Health Insurance Research Database. All patients with IE between January 2000 and December 2010 were enrolled. The primary outcome was in-hospital mortality. The secondary outcome included all-cause mortality within the first 3 months, 6 months, and one year after the diagnosis of IE. Among 13,584 patients with IE, we applied propensity score-matching on a 1:4 ratio, in which 370 statin users were matched to 1,480 statin non-users. Compared with statin non-users, statin users had a significantly lower risk of in-hospital mortality (adjusted hazard ratio [aHR] 0.65, 95% confidence interval [CI], 0.49-0.86). The reduction in mortality from IE remained significant for follow-up 3 months (aHR 0.68,95% CI, 0.53-0.88), 6 months (aHR 0.73,95% CI, 0.58-0.91), and 12 months (AIR 0.68,95% CI, 0.55-0.84). Statin therapy was associated with a reduced risk of ICU admission rates, shock events, the need for mechanical ventilation, but not significantly with the need for heart valvular replacement surgery. In conclusion, our study found that statin therapy is associated with a reduced risk of in-hospital and subsequent mortality of IE. (C) 2014 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.amjcard.2014.03.064
http://hdl.handle.net/11536/24616
ISSN: 0002-9149
DOI: 10.1016/j.amjcard.2014.03.064
期刊: AMERICAN JOURNAL OF CARDIOLOGY
Volume: 114
Issue: 1
起始頁: 94
結束頁: 99
顯示於類別:期刊論文


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  1. 000338481500016.pdf