標題: Development of a Growth- Hormone- Conjugated Nanodiamond Complex for Cancer Therapy
作者: Chu, Hsueh-Liang
Chen, Hung-Wei
Tseng, Shin-Hua
Hsu, Ming-Hua
Ho, Li-Ping
Chou, Fu-Hsuan
Li, MD. PhD. Hsing-Yuan
Chang, Yu-Chuan
Chen, Pei-Hsin
Tsai, Li-Yun
Chou, Ching-Chung
Chen, Jyh Shin
Cheng, Tsai-Mu
Chang, Chia-Ching
材料科學與工程學系
生物科技學系
Department of Materials Science and Engineering
Department of Biological Science and Technology
關鍵字: A549 lung cancer cells;apoptosis;lasers;nanodiamond complexes;recombinant growth hormones
公開日期: 1-五月-2014
摘要: It is highly desirable to develop a therapeutic, observable nanoparticle complex for specific targeting in cancer therapy. Growth hormone (GH) and its antagonists have been explored as cancer cell-targeting molecules for both imaging and therapeutic applications. In this study, a low toxicity, biocompatible, therapeutic, and observable GH-nanoparticle complex for specifically targeting growth hormone receptor (GHR) in cancer cells was synthesized by conjugating GH with green fluorescence protein and carboxylated nanodiamond. Moreover, we have shown that this complex can be triggered by laser irradiation to create a nanoblast and induce cell death in the A549 non-small-cell lung cancer cell line via the apoptotic pathway. This laser-mediated, cancer-targeting platform can be widely used in cancer therapy.
URI: http://dx.doi.org/10.1002/cmdc.201300541
http://hdl.handle.net/11536/24464
ISSN: 1860-7179
DOI: 10.1002/cmdc.201300541
期刊: CHEMMEDCHEM
Volume: 9
Issue: 5
起始頁: 1023
結束頁: 1029
顯示於類別:期刊論文


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  1. 000335001700017.pdf