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dc.contributor.authorWang, Hao-Chingen_US
dc.contributor.authorHo, Chun-Hanen_US
dc.contributor.authorHsu, Kai-Chengen_US
dc.contributor.authorYang, Jinn-Moonen_US
dc.contributor.authorWang, Andrew H. -J.en_US
dc.date.accessioned2014-12-08T15:36:05Z-
dc.date.available2014-12-08T15:36:05Z-
dc.date.issued2014-05-13en_US
dc.identifier.issn0006-2960en_US
dc.identifier.urihttp://dx.doi.org/10.1021/bi5002689en_US
dc.identifier.urihttp://hdl.handle.net/11536/24426-
dc.description.abstractDNA mimic proteins have DNA-like negative surface charge distributions, and they function by occupying the DNA binding sites of DNA binding proteins to prevent these sites from being accessed by DNA. DNA mimic proteins control the activities of a variety of DNA binding proteins and are involved in a wide range of cellular mechanisms such as chromatin assembly, DNA repair, transcription regulation, and gene recombination. However, the sequences and structures of DNA mimic proteins are diverse, making them difficult to predict by bioinformatic search. To date, only a few DNA mimic proteins have been reported. These DNA mimics were not found by searching for functional motifs in their sequences but were revealed only by structural analysis of their charge distribution. This review highlights the biological roles and structures of 16 reported DNA mimic proteins. We also discuss approaches that might be used to discover new DNA mimic proteins.en_US
dc.language.isoen_USen_US
dc.titleDNA Mimic Proteins: Functions, Structures, and Bioinformatic Analysisen_US
dc.typeArticleen_US
dc.identifier.doi10.1021/bi5002689en_US
dc.identifier.journalBIOCHEMISTRYen_US
dc.citation.volume53en_US
dc.citation.issue18en_US
dc.citation.spage2865en_US
dc.citation.epage2874en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000336020000001-
dc.citation.woscount3-
Appears in Collections:Articles


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