標題: DNA Mimic Proteins: Functions, Structures, and Bioinformatic Analysis
作者: Wang, Hao-Ching
Ho, Chun-Han
Hsu, Kai-Cheng
Yang, Jinn-Moon
Wang, Andrew H. -J.
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 13-May-2014
摘要: DNA mimic proteins have DNA-like negative surface charge distributions, and they function by occupying the DNA binding sites of DNA binding proteins to prevent these sites from being accessed by DNA. DNA mimic proteins control the activities of a variety of DNA binding proteins and are involved in a wide range of cellular mechanisms such as chromatin assembly, DNA repair, transcription regulation, and gene recombination. However, the sequences and structures of DNA mimic proteins are diverse, making them difficult to predict by bioinformatic search. To date, only a few DNA mimic proteins have been reported. These DNA mimics were not found by searching for functional motifs in their sequences but were revealed only by structural analysis of their charge distribution. This review highlights the biological roles and structures of 16 reported DNA mimic proteins. We also discuss approaches that might be used to discover new DNA mimic proteins.
URI: http://dx.doi.org/10.1021/bi5002689
http://hdl.handle.net/11536/24426
ISSN: 0006-2960
DOI: 10.1021/bi5002689
期刊: BIOCHEMISTRY
Volume: 53
Issue: 18
起始頁: 2865
結束頁: 2874
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