Title: Directly Thiolated Modification onto the Surface of Detonation Nanodiamonds
Authors: Hsu, Ming-Hua
Chuang, Hong
Cheng, Fong-Yu
Huang, Ying-Pei
Han, Chien-Chung
Chen, Jiun-Yu
Huang, Su-Chin
Chen, Jen-Kun
Wu, Dian-Syue
Chu, Hsueh-Liang
Chang, Chia-Ching
Department of Biological Science and Technology
Keywords: thiolated;nanodiamond;detonation nanodiamond;surface modification;thiolated nanodiamond;functionalized nanodiamond
Issue Date: 28-May-2014
Abstract: An efficient method for modifying the surface of detonation nanodiamonds (5 and 100 nm) with thiol groups (-SH) by using an organic chemistry strategy is presented herein. Thiolated nanodiamonds were characterized by spectroscopic techniques, and the atomic percentage of sulfur was analyzed by elemental analysis and X-ray photoelectron spectroscopy. The conjugation between thiolated nanodiamonds and gold nanoparticles was elucidated by transmission electron microscopy and UV-vis spectrometry. Moreover, the material did not show significant cytotoxicity to the human lung carcinoma cell line and may prospectively be applied in bioconjugated technology. The new method that we elucidated may significantly improve the approach to surface modification of detonation nanodiamonds and build up a new platform for the application of nanodiamonds.
URI: http://dx.doi.org/10.1021/am500324z
ISSN: 1944-8244
DOI: 10.1021/am500324z
Volume: 6
Issue: 10
Begin Page: 7198
End Page: 7203
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