標題: Yeast Oropharyngeal Colonization in Human Immunodeficiency Virus-Infected Patients in Central Taiwan
作者: Ho, Mao-Wang
Yang, Yun-Liang
Lin, Chih-Chao
Chi, Chih-Yu
Chen, Hui-Ting
Lin, Po-Chang
Hsieh, Li-Yun
Chou, Chia-Hui
Chu, Wen-Li
Wu, Chiou-Pyng
Lauderdale, Tsai-Ling
Lo, Hsiu-Jung
生物科技學系
分子醫學與生物工程研究所
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
關鍵字: Human immunodeficiency virus;HIV;Colonization;Mixed yeast
公開日期: 1-六月-2014
摘要: A prospective, cross-sectional study was conducted at a medical center in central Taiwan to understand the prevalence, associated factors, and microbiologic features for oropharyngeal yeast colonization in human immunodeficiency virus-infected outpatients. Oral yeast colonization was detected in 127 (45 %) patients, including 21 (16.5 %) colonized by more than one species. Of the 154 isolates, Candida albicans was the most common species (114, 74 %), followed by Candida dubliniensis (10, 6.5 %), Candida glabrata (10, 6.5 %), Candida tropicalis (7, 4.5 %), and 13 others. We found that receiving antituberculous drug (p = 0.046) or atazanavir (p = 0.045) was two predictors for patients colonized by non-C. albicans species (p = 0.005) and risking mixed yeast colonization (p = 0.009). Even though our data showed that clinical antifungal drugs remained effective in vitro against the colonizing yeasts, the increased mixed yeast colonization indicates a potential issue for controlling mixed infections in hospital settings.
URI: http://dx.doi.org/10.1007/s11046-014-9753-5
http://hdl.handle.net/11536/24406
ISSN: 0301-486X
DOI: 10.1007/s11046-014-9753-5
期刊: MYCOPATHOLOGIA
Volume: 177
Issue: 5-6
起始頁: 309
結束頁: 317
顯示於類別:期刊論文


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