標題: Investigating microRNA-Target Interaction-Supported Tissues in Human Cancer Tissues Based on miRNA and Target Gene Expression Profiling
作者: Hsieh, Wan J.
Lin, Feng-Mao
Huang, Hsien-Da
Wang, Hsiuying
生物資訊及系統生物研究所
統計學研究所
Institude of Bioinformatics and Systems Biology
Institute of Statistics
公開日期: 22-四月-2014
摘要: Recent studies have revealed that a small non-coding RNA, microRNA (miRNA) down-regulates its mRNA targets. This effect is regarded as an important role in various biological processes. Many studies have been devoted to predicting miRNA-target interactions. These studies indicate that the interactions may only be functional in some specific tissues, which depend on the characteristics of an miRNA. No systematic methods have been established in the literature to investigate the correlation between miRNA-target interactions and tissue specificity through microarray data. In this study, we propose a method to investigate miRNA-target interaction-supported tissues, which is based on experimentally validated miRNA-target interactions. The tissue specificity results by our method are in accordance with the experimental results in the literature.
URI: http://dx.doi.org/10.1371/journal.pone.0095697
http://hdl.handle.net/11536/24226
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0095697
期刊: PLOS ONE
Volume: 9
Issue: 4
結束頁: 
顯示於類別:期刊論文


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  1. 000335240300076.pdf