標題: Association of Interleukin-16 Polymorphisms with Graves' Disease in a Taiwanese Population
作者: Tsai, Kun-Hsi
Chang, Ching-Yao
Tsai, Fuu-Jen
Lin, Hui-Ju
Yang, Yuh-Shyong
Lim, Yun-Ping
Liao, Chiu-Chu
Wan, Lei
生物科技學系
Department of Biological Science and Technology
關鍵字: Graves' disease;IL-16;polymorphisms
公開日期: 30-Apr-2014
摘要: Graves' disease (GD) is a complex, organ-specific autoimmune disease wherein the thyroid gland becomes enlarged and overactive. During GD progression, T cells secrete interleukin-16 (IL-16) to promote inflammation, act as chemoattractants that recruit more inflammatory cells, and activate target cells to enhance the development of GD. To investigate the role of IL-16 in GD, we genotyped 474 patients with GD at 8 single-nucleotide polymorphisms (SNPs) in the IL-16 gene. The IL-16 SNP rs8028364 was found to be associated with GD when compared with the control subjects (P = 2.93 x 10(-17); CG genotype: odds ratio [OR] = 0.2 [0.07, 0.59]; CC genotype: OR = 0.03 [0.01, 0.09]). The rs1131445 polymorphism was found to be associated with GD under the allelic model (P = 0.01; G allele: OR = 1.97 [1.17, 3.32]). Sliding-window haplotype analysis by the PLINK program showed that the most significant haplotype was provided by the 6-SNP haplotype window, consisting of rs7182786, rs8028364, rs12907134, rs4128767, rs4072111 and rs8031107 (P = 2.31 x 10(-51)). We found 2 protective haplotypes: GCAAGG (P = 8.69 x 10(-7); OR = 0.22 [0.12, 0.41]) and AGAAGG (P = 0.0012; OR = 0.26 [0.12, 0.6]). In addition, GGGGAA (P = 0.39; OR = 2.32 [1.08, 4.99]) and GGGAGA (P = 1.18 x 10(-5); OR = 5.54 [2.50, 12.31]) were found to be the two high-risk haplotypes. These results suggest that polymorphisms in IL-16 may be used as genetic markers for the diagnosis and prognosis of GD.
URI: http://dx.doi.org/10.4077/CJP.2014.BAB150
http://hdl.handle.net/11536/24218
ISSN: 0304-4920
DOI: 10.4077/CJP.2014.BAB150
期刊: CHINESE JOURNAL OF PHYSIOLOGY
Volume: 57
Issue: 2
起始頁: 69
結束頁: 75
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