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dc.contributor.authorChuang, Ching-Chengen_US
dc.contributor.authorNakagome, Kazuyukien_US
dc.contributor.authorPu, Shenghongen_US
dc.contributor.authorLan, Tsuo-Hungen_US
dc.contributor.authorLee, Chia-Yenen_US
dc.contributor.authorSun, Chia-Weien_US
dc.date.accessioned2014-12-08T15:35:39Z-
dc.date.available2014-12-08T15:35:39Z-
dc.date.issued2014-01-01en_US
dc.identifier.issn1083-3668en_US
dc.identifier.urihttp://dx.doi.org/10.1117/1.JBO.19.1.011006en_US
dc.identifier.urihttp://hdl.handle.net/11536/24062-
dc.description.abstractAbnormal prefrontal function plays a central role in the cognition deficits of schizophrenic patients; however, the character of the relationship between discriminant analysis and prefrontal activation remains undetermined. Recently, evidence of low prefrontal cortex (PFC) activation in individuals with schizophrenia has also been found during verbal fluency tests (VFT) and other cognitive tests with several neuroimaging methods. The purpose of this study is to assess the hemodynamic changes of the PFC and discriminant analysis between schizophrenia patients and healthy controls during VFT task by utilizing functional optical topography. A total of 99 subjects including 53 schizophrenic patients and 46 age- and gender-matched healthy controls were studied. The results showed that the healthy group had larger activation in the right and left PFC than in the middle PFC. Besides, the schizophrenic group showed weaker task performance and lower activation in the whole PFC than the healthy group. The result of the discriminant analysis showed a significant difference with P value <0.001 in six channels (CH 23, 29, 31, 40, 42, 52) between the schizophrenic and healthy groups. Finally, 68.69% and 71.72% of subjects are correctly classified as being schizophrenic or healthy with all 52 channels and six significantly different channels, respectively. Our findings suggest that the left PFC can be a feature region for discriminant analysis of schizophrenic diagnosis. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.en_US
dc.language.isoen_USen_US
dc.subjectschizophreniaen_US
dc.subjectprefrontal cortex dysfunctionen_US
dc.subjectfunctional optical topographyen_US
dc.subjectdiscriminant analysisen_US
dc.subjectnear-infrared spectroscopyen_US
dc.titleDiscriminant analysis of functional optical topography for schizophrenia diagnosisen_US
dc.typeArticleen_US
dc.identifier.doi10.1117/1.JBO.19.1.011006en_US
dc.identifier.journalJOURNAL OF BIOMEDICAL OPTICSen_US
dc.citation.volume19en_US
dc.citation.issue1en_US
dc.citation.epageen_US
dc.contributor.department光電工程學系zh_TW
dc.contributor.departmentDepartment of Photonicsen_US
dc.identifier.wosnumberWOS:000331892700007-
dc.citation.woscount2-
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