標題: Discriminant analysis of functional optical topography for schizophrenia diagnosis
作者: Chuang, Ching-Cheng
Nakagome, Kazuyuki
Pu, Shenghong
Lan, Tsuo-Hung
Lee, Chia-Yen
Sun, Chia-Wei
光電工程學系
Department of Photonics
關鍵字: schizophrenia;prefrontal cortex dysfunction;functional optical topography;discriminant analysis;near-infrared spectroscopy
公開日期: 1-Jan-2014
摘要: Abnormal prefrontal function plays a central role in the cognition deficits of schizophrenic patients; however, the character of the relationship between discriminant analysis and prefrontal activation remains undetermined. Recently, evidence of low prefrontal cortex (PFC) activation in individuals with schizophrenia has also been found during verbal fluency tests (VFT) and other cognitive tests with several neuroimaging methods. The purpose of this study is to assess the hemodynamic changes of the PFC and discriminant analysis between schizophrenia patients and healthy controls during VFT task by utilizing functional optical topography. A total of 99 subjects including 53 schizophrenic patients and 46 age- and gender-matched healthy controls were studied. The results showed that the healthy group had larger activation in the right and left PFC than in the middle PFC. Besides, the schizophrenic group showed weaker task performance and lower activation in the whole PFC than the healthy group. The result of the discriminant analysis showed a significant difference with P value <0.001 in six channels (CH 23, 29, 31, 40, 42, 52) between the schizophrenic and healthy groups. Finally, 68.69% and 71.72% of subjects are correctly classified as being schizophrenic or healthy with all 52 channels and six significantly different channels, respectively. Our findings suggest that the left PFC can be a feature region for discriminant analysis of schizophrenic diagnosis. (C) The Authors. Published by SPIE under a Creative Commons Attribution 3.0 Unported License. Distribution or reproduction of this work in whole or in part requires full attribution of the original publication, including its DOI.
URI: http://dx.doi.org/10.1117/1.JBO.19.1.011006
http://hdl.handle.net/11536/24062
ISSN: 1083-3668
DOI: 10.1117/1.JBO.19.1.011006
期刊: JOURNAL OF BIOMEDICAL OPTICS
Volume: 19
Issue: 1
結束頁: 
Appears in Collections:Articles


Files in This Item:

  1. 000331892700007.pdf