標題: Increased Risk of Major Depression in the Three Years following a Femoral Neck Fracture-A National Population-Based Follow-Up Study
作者: Chang, Chih-Yu
Chen, Wen-Liang
Liou, Yi-Fan
Ke, Chih-Chi
Lee, Hua-Chin
Huang, Hui-Ling
Ciou, Li-Ping
Chou, Chu-Chung
Yang, Mei-Chueh
Ho, Shinn-Ying
Lin, Yan-Ren
生物科技學系
生物資訊及系統生物研究所
多媒體工程研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Institute of Multimedia Engineering
公開日期: 13-三月-2014
摘要: Femoral neck fracture is common in the elderly, and its impact has increased in aging societies. Comorbidities, poor levels of activity and pain may contribute to the development of depression, but these factors have not been well addressed. This study aims to investigate the frequency and risk of major depression after a femoral neck fracture using a nationwide population-based study. The Taiwan Longitudinal Health Insurance Database was used in this study. A total of 4,547 patients who were hospitalized for femoral neck fracture within 2003 to 2007 were recruited as a study group; 13,641 matched non-fracture participants were enrolled as a comparison group. Each patient was prospectively followed for 3 years to monitor the occurrence of major depression. Cox proportional-hazards models were used to compute the risk of major depression between members of the study and comparison group after adjusting for residence and sociodemographic characteristics. The most common physical comorbidities that were present after the fracture were also analyzed. The incidences of major depression were 1.2% (n = 55) and 0.7% (n = 95) in the study and comparison groups, respectively. The stratified Cox proportional analysis showed a covariate-adjusted hazard ratio of major depression among patients with femoral neck fracture that was 1.82 times greater (95% CI, 1.30-2.53) than that of the comparison group. Most major depressive episodes (34.5%) presented within the first 200 days following the fracture. In conclusion, patients with a femoral neck fracture are at an increased risk of subsequent major depression. Most importantly, major depressive episodes mainly occurred within the first 200 days following the fracture.
URI: http://dx.doi.org/10.1371/journal.pone.0089867
http://hdl.handle.net/11536/23980
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0089867
期刊: PLOS ONE
Volume: 9
Issue: 3
結束頁: 
顯示於類別:期刊論文


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