標題: Synthetic heparin and heparan sulfate oligosaccharides and their protein interactions
作者: Zulueta, Medel Manuel L.
Lin, Shu-Yi
Hu, Yu-Peng
Hung, Shang-Cheng
應用化學系
Department of Applied Chemistry
公開日期: 1-十二月-2013
摘要: Heparin and heparan sulfate bind a host of basic proteins that take advantage of the sugar's dense structural information. The significance of these interactions in various aspects of development, physiology, and disease stimulated keen interest in evaluating structure-activity relationships. The well-defined heparin and heparan sulfate oligosaccharides needed for these studies can be mainly accessed by chemical synthesis and, more recently by chemoenzymatic means. The various synthetic strategies available to chemical synthesis have recently enabled the acquisition of several regular and irregular sequences, including a number of dodecasaccharides, through improved coupling methods and judicial protecting group manipulations. Controlled chain elongation and critical application of modification enzymes allowed the generation of well-defined constructs via chemoenzymatie synthesis. Investigations of various protein interactions with the synthetic constructs delivered valuable information that could aid future drug development endeavors.
URI: http://dx.doi.org/10.1016/j.cbpa.2013.10.008
http://hdl.handle.net/11536/23654
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2013.10.008
期刊: CURRENT OPINION IN CHEMICAL BIOLOGY
Volume: 17
Issue: 6
起始頁: 1023
結束頁: 1029
顯示於類別:期刊論文


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  1. 000329601100022.pdf