標題: Hypoxic-State Estimation of Brain Cells by Using Wireless Near-Infrared Spectroscopy
作者: Kuo, Jinn-Rung
Lin, Bor-Shyh
Cheng, Chih-Lun
Chio, Chung-Ching
影像與生醫光電研究所
Institute of Imaging and Biomedical Photonics
關鍵字: Cerebra ischemia;hypoxic state;microdylasis;near-infrared spectroscopy (NIRS)
公開日期: 1-一月-2014
摘要: Near-infrared spectroscopy (NIRS) is a modern measuring technology in neuroscience. It can be used to noninvasively measure the relative concentrations of oxyhemoglobin (OxyHb) and deoxyhemoglobin (DeoHb), which can reflect information related to cerebral blood volume and cerebral oxygen saturation. Therefore, it has the potential for noninvasive monitoring of cerebral ischemia. However, there is still a lack of reliable physiological information on the relationship between the concentrations of OxyHb and DeoHb in cerebral blood and the exact hypoxic state of brain cells under cerebral ischemia. In this study, we describe a wireless multichannel NIRS system, which we designed to noninvasively monitor the relative concentrations of OxyHb and DeoHb in bilateral cerebral blood before, during, and after middle cerebral artery occlusion. By comparing the results with the lactate/pyruvate ratio measured by microdialysis, we investigated the correlation between the relative concentrations of OxyHb and DeoHb in cerebral blood and the hypoxic state of brain cells. The results showed that the relationship between the concentration changes of DeoHb in cerebral blood and the hypoxic state of brain cells was significant. Therefore, by monitoring the changes in concentrations of DeoHb, the wireless NIRS can be used to estimate the hypoxic state of brain cells indirectly.
URI: http://dx.doi.org/10.1109/JBHI.2013.2261310
http://hdl.handle.net/11536/23635
ISSN: 2168-2194
DOI: 10.1109/JBHI.2013.2261310
期刊: IEEE JOURNAL OF BIOMEDICAL AND HEALTH INFORMATICS
Volume: 18
Issue: 1
起始頁: 167
結束頁: 173
顯示於類別:期刊論文


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