Title: Distribution and drug susceptibilities of Candida species causing candidemia from a medical center in central Taiwan
Authors: Chang, Te-Pin
Ho, Mao-Wang
Yang, Yun-Liang
Lo, Pai-Chang
Lin, Pei-Sheng
Wang, An-Huei
Lo, Hsiu-Jung
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
Keywords: Amphotericin B;Azoles;Candida species;Candidemia;Drug susceptibility;Echinocandins
Issue Date: 1-Dec-2013
Abstract: Invasive fungal infections have increased significantly in the past few decades because of the increase in high-risk populations. To investigate the distribution and drug susceptibilities of such infections, we analyzed all 152 Candida isolates causing candidemia from 2004 to 2006 at the China Medical University Hospital, a medical center in central Taiwan. Candida albicans was the most common species, accounting for 52.6 % of the isolates, followed by C. tropicalis (19.7 %), C. parapsilosis (14.5 %), C. glabrata (8.6 %), C. guilliermondii (3.9 %), and C. pelliculosa (0.7 %). All isolates were susceptible to amphotericin B, anidulafungin, micafungin, and voriconazole according to minimum inhibitory concentrations (MICs) after a 24-h incubation; 0.7 %, 6.6 %, and 7.9 % of isolates were resistant to amphotericin B, fluconazole, and voriconazole, respectively, after 48-h incubation. Both C. albicans and C. parapsilosis had high degrees of agreement for azoles between 24- and 48-h incubation periods, whereas C. glabrata (38.5-46.2 %) and C. tropicalis (56.7-63.3 %) did not. The majority of the isolates with high azole MICs displayed a trailing growth phenotype. Hence, the MICs of different drugs after 24-h incubation may be considered for prognosis of candidemia.
URI: http://dx.doi.org/10.1007/s10156-013-0623-8
ISSN: 1341-321X
DOI: 10.1007/s10156-013-0623-8
Volume: 19
Issue: 6
Begin Page: 1065
End Page: 1071
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