標題: Enhancement of cancer therapy efficacy by trastuzumab-conjugated and pH-sensitive nanocapsules with the simultaneous encapsulation of hydrophilic and hydrophobic compounds
作者: Chiang, Chih-Sheng
Hu, Shang-Hsiu
Liao, Bang-Jie
Chang, Yuan-Ching
Chen, San-Yuan
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Emulsion;pH sensitive;HER-2 positive breast cancer;Trastuzumab;Co-delivery
公開日期: 1-Jan-2014
摘要: Trastuzumab-conjugated pH-sensitive double emulsion nanocapsules (DENCs) stabilized by a single-component Poly (vinyl alcohol) (PVA) with magnetic nanoparticles can be fabricated through a two-step double emulsion process; these nanocapsules can be used to encapsulate hydrophilic doxorubicin (Dox) and hydrophobic paclitaxel (PTX) simultaneously. When PMA(SH) was attached to the shell of the DENCs, enhanced dual drug release of PTX/Dox was detected, specifically in intracellular acidic pH environments. The targeting ability of these Trastuzumab-conjugated DENCs was demonstrated with confocal images, which revealed a significantly elevated cellular uptake in HER-2 overexpressing SkBr3 cells. More importantly, an intravenous injection of this co-delivery system followed by magnetic targeting (MT) chemotherapy suppressed cancer growth in vivo more efficiently than the delivery of either PTX or Dox alone. The integration of the functionalities makes this combination therapy system a powerfully new tool for in vitro/in vivo cancer therapy, especially for in HER-2 positive cancers. From the Clinical Editor: Trastuzumab-conjugated pH-sensitive nanocapsules were used in this study for simultaneous targeted delivery of hydrophobic (PTX) and hydrophilic (Dox) anti-cancer agents to HER-2 positive cancer cells. Additional use of magnetic targeting demonstrated superior efficacy of this delivery system compared to PTX or Dox alone. (C) 2014 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.nano.2013.07.009
http://hdl.handle.net/11536/23393
ISSN: 1549-9634
DOI: 10.1016/j.nano.2013.07.009
期刊: NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE
Volume: 10
Issue: 1
起始頁: 99
結束頁: 107
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