Title: A Fully Integrated 8-Channel Closed-Loop Neural-Prosthetic CMOS SoC for Real-Time Epileptic Seizure Control
Authors: Chen, Wei-Ming
Chiueh, Herming
Chen, Tsan-Jieh
Ho, Chia-Lun
Jeng, Chi
Ker, Ming-Dou
Lin, Chun-Yu
Huang, Ya-Chun
Chou, Chia-Wei
Fan, Tsun-Yuan
Cheng, Ming-Seng
Hsin, Yue-Loong
Liang, Sheng-Fu
Wang, Yu-Lin
Shaw, Fu-Zen
Huang, Yu-Hsing
Yang, Chia-Hsiang
Wu, Chung-Yu
Undergraduate Honors Program of Electrical Engineering and Computer Science
Department of Electronics Engineering and Institute of Electronics
Biomedical Electronics Translational Research Center
Keywords: Closed-loop control;epilepsy;neuron modulation;neural prosthesis;system-on-Chip (SoC);wireless power transmission
Issue Date: 1-Jan-2014
Abstract: An 8-channel closed-loop neural-prosthetic SoC is presented for real-time intracranial EEG (iEEG) acquisition, seizure detection, and electrical stimulation in order to suppress epileptic seizures. The SoC is composed of eight energy-efficient analog front-end amplifiers (AFEAs), a 10-b delta-modulated SAR ADC (DMSAR ADC), a configurable bio-signal processor (BSP), and an adaptive high-voltage-tolerant stimulator. A wire-less power-and-data transmission system is also embedded. By leveraging T-connected pseudo-resistors, the high-pass (low-pass) cutoff frequency of the AFEAs can be adjusted from 0.1 to 10 Hz (0.8 to 7 kHz). The noise-efficiency factor (NEF) of the AFEA is 1.77, and the DMSAR ADC achieves an ENOB of 9.57 bits. The BSP extracts the epileptic features from time-domain entropy and frequency spectrum for seizure detection. A constant 30-mu A stimulus current is delivered by closed-loop control. The acquired signals are transmitted with on-off keying (OOK) modulation at 4 Mbps over the MedRadio band for monitoring. A multi-LDO topology is adopted to mitigate the interferences across different power domains. The proposed SoC is fabricated in 0.18-mu m CMOS and occupies 13.47 mm(2). Verified on Long Evans rats, the proposed SoC dissipates 2.8 mW and achieves high detection accuracy 92% within 0.8 s.
URI: http://dx.doi.org/10.1109/JSSC.2013.2284346
ISSN: 0018-9200
DOI: 10.1109/JSSC.2013.2284346
Volume: 49
Issue: 1
Begin Page: 232
End Page: 247
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