Title: Ionic liquid supported multistep divergent synthesis of benzimidazole linked pyrrolo-/pyrido-/isoindolo-benzimidazolones
Authors: Thummanagoti, Suman
Yellol, Gorakh S.
Sun, Chung-Ming
Department of Applied Chemistry
Keywords: Ionic liquid support;Microwave synthesis;Cascade reaction;Bis-heterocycles;Benzimidazoles
Issue Date: 1-Jun-2011
Abstract: Diversity oriented parallel synthesis for bis-heterocyclic skeletal novel benzimidazole linked pyrrolo-/pyrido-benzimidazolones and benzimidazole linked isoindolo-benzimidazolones has been developed on ionic liquid support under microwave irradiation by utilizing the cascade cyclization. The key tandem transformation comprises (i) amino-alkylation of immobilized o-phenylenediamine with ketoacids, (ii) intramolecular cyclization through secondary amine on electrophilic imine carbon toward pentacyclic aza-ring and (iii) second amido-cyclization to deliver cycloamide ring. The synergy arises by combined use of microwave heating with ionic liquid support which is very effectively used to speed up multistep synthesis of biological interesting heterocycles. (C) 2011 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.tetlet.2011.03.046
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2011.03.046
Volume: 52
Issue: 22
Begin Page: 2818
End Page: 2822
Appears in Collections:Articles