標題: The Methanol Extract of Angelica sinensis Induces Cell Apoptosis and Suppresses Tumor Growth in Human Malignant Brain Tumors
作者: Lin, Yu-Ling
Lai, Wen-Lin
Harn, Horng-jyh
Hung, Pei-Hsiu
Hsieh, Ming-Chang
Chang, Kai-Fu
Huang, Xiao-Fan
Liao, Kuang-Wen
Lee, Ming-Shih
Tsai, Nu-Man
生物科技學院
生物資訊及系統生物研究所
分子醫學與生物工程研究所
College of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
Institute of Molecular Medicine and Bioengineering
公開日期: 2013
摘要: Glioblastoma multiforme (GBM) is a highly vascularized and invasive neoplasm. The methanol extract of Angelica sinensis (AS-M) is commonly used in traditional Chinese medicine to treat several diseases, such as gastric mucosal damage, hepatic injury, menopausal symptoms, and chronic glomerulonephritis. AS-M also displays potency in suppressing the growth of malignant brain tumor cells. The growth suppression of malignant brain tumor cells by AS-M results from cell cycle arrest and apoptosis. AS-M upregulates expression of cyclin kinase inhibitors, including p16, to decrease the phosphorylation of Rb proteins, resulting in arrest at the G(0)-G(1) phase. The expression of the p53 protein is increased by AS-M and correlates with activation of apoptosis-associated proteins. Therefore, the apoptosis of cancer cells induced by AS-M may be triggered through the p53 pathway. In in vivo studies, AS-M not only suppresses the growth of human malignant brain tumors but also significantly prolongs patient survival. In addition, AS-M has potent anticancer effects involving cell cycle arrest, apoptosis, and antiangiogenesis. The in vitro and in vivo anticancer effects of AS-M indicate that this extract warrants further investigation and potential development as a new antibrain tumor agent, providing new hope for the chemotherapy of malignant brain cancer.
URI: http://hdl.handle.net/11536/23177
http://dx.doi.org/10.1155/2013/394636
ISSN: 1741-427X
DOI: 10.1155/2013/394636
期刊: EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE
顯示於類別:期刊論文


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