標題: Palladium-catalyzed regioselective synthesis of 2(2 '-biphenyl)benzimidazoles through C-H activation
作者: Chen, Li-Hsun
Wu, Tz-Yi
Paike, Vijaykumar
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Palladium catalyst;C-H activation;C-C bond formation;Benzimidazole;Biphenyl heterocycles
公開日期: 1-十一月-2013
摘要: An efficient palladium-catalyzed strategy through C-H bond activation for the synthesis of 2(2-biphenyl)-benzimidazoles is reported herein. The regioselective C-C bond formation proceeds in a sealed tube via oxidative C-H activation of ortho-directed 2-aryl-benzimidazole to couple with various iodobenzene analogs in high yields. This arylation exhibited high regioselectivity which is able to increase molecular diversity in difficult functionalized positions of parent molecules. This strategy provides a convenient and simple synthesis of biphenyl heterocyclic compounds with high regioselectivity.
URI: http://dx.doi.org/10.1007/s11030-013-9460-z
http://hdl.handle.net/11536/22956
ISSN: 1381-1991
DOI: 10.1007/s11030-013-9460-z
期刊: MOLECULAR DIVERSITY
Volume: 17
Issue: 4
起始頁: 641
結束頁: 649
顯示於類別:期刊論文


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  1. 000325716200002.pdf