Title: A Pyrene-based Highly Selective Turn-on Fluorescent Chemosensor for Iron(III) Ions and its Application in Living Cell Imaging
Authors: Chung, Peter Kun
Liu, Shi-Rong
Wang, Hsuan-Fu
Wu, Shu-Pao
Department of Applied Chemistry
Keywords: Sensors;Iron;Pyrene;Imaging agents
Issue Date: 1-Nov-2013
Abstract: A new pyrene-based chemosensor (1) exhibits excellent selectivity for Fe3+ ions over a wide range of tested metal ions Ag+, Ca2+, Cd2+, Co2+, Cu2+, Fe2+, Hg2+, K+, Mg2+, Mn2+, Ni2+, Pb2+, and Zn2+. The binding of Fe3+ to chemosensor 1 produces an emission band at 507 nm due to the formation of a Py-Py* excimer that is induced by Fe3+-binding. The binding ratio of 1-Fe3+ was determined to be 1:1 from a Job plot. The association constant of 1-Fe3+ complexes was found to be 1.27 x 10(4) M-1 from a Benesi-Hildebrand plot. In addition, fluorescence microscopy experiments show that 1 can be used as a fluorescent probe for detecting Fe3+ in living cells.
URI: http://dx.doi.org/10.1007/s10895-013-1242-6
ISSN: 1053-0509
DOI: 10.1007/s10895-013-1242-6
Volume: 23
Issue: 6
Begin Page: 1139
End Page: 1145
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