標題: Resuscitation from experimental traumatic brain injury by magnolol therapy
作者: Wang, Che-Chuan
Lin, Kao-Chang
Lin, Bor-Shyh
Chio, Chung-Ching
Kuo, Jinn-Rung
影像與生醫光電研究所
Institute of Imaging and Biomedical Photonics
關鍵字: Traumatic brain injury;Magnolol;Free radical scavenger;Neuronal apoptosis;Transforming growth factor beta 1
公開日期: 1-Oct-2013
摘要: Background: The purpose of the present study was to determine whether magnolol, a free radical scavenger, mitigates the deleterious effects of traumatic brain injury (TBI). Material and methods: Traumatic brain injuries were induced in anesthetized male Sprague-Dawley rats using fluid percussion, and the rats were divided into groups treated with magnolol (2 mg/kg, intravenously) or vehicle. A group of rats that did not undergo TBI induction was also studied as controls. Biomarkers of TBI, including glycerol and 2,3-dihydroxybenzoic acid, were evaluated by microdialysis. Infraction volume, extent of neuronal apoptosis, and antiapoptosis factor transforming growth factor beta 1 (TGF-beta 1) were also measured. Functional outcomes were assessed by motor assays. Results: Compared with the rats without TBI, the animals with TBI exhibited higher hippocampal glycerol and 2,3-dihydroxybenzoic acid. Relative to the vehicle-treated group, the magnolol-treated group showed decreased hippocampal levels of glycerol and hydroxyl radical levels. The magnolol-treated rats also exhibited decreased cerebral infarction volume and neuronal apoptosis and increased antiapoptosis-associated factor TGF-beta 1 expression. These effects were translated into improved motor function post TBI. Conclusions: Our results suggest that intravenous magnolol injection mitigates the deleterious effects of TBI in rats based on its potent free radical scavenging capability, and the mechanism of anti-neuronal apoptosis is partly due to an increase in TGF-beta 1 expression in the ischemic cortex. (C) 2013 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jss.2013.04.059
http://hdl.handle.net/11536/22738
ISSN: 0022-4804
DOI: 10.1016/j.jss.2013.04.059
期刊: JOURNAL OF SURGICAL RESEARCH
Volume: 184
Issue: 2
起始頁: 1045
結束頁: 1052
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