標題: Fungal Small RNAs Suppress Plant Immunity by Hijacking Host RNA Interference Pathways
作者: Weiberg, Arne
Wang, Ming
Lin, Feng-Mao
Zhao, Hongwei
Zhang, Zhihong
Kaloshian, Isgouhi
Huang, Hsien-Da
Jin, Hailing
生物科技學系
生物資訊及系統生物研究所
Department of Biological Science and Technology
Institude of Bioinformatics and Systems Biology
公開日期: 4-Oct-2013
摘要: Botrytis cinerea, the causative agent of gray mold disease, is an aggressive fungal pathogen that infects more than 200 plant species. Here, we show that some B. cinerea small RNAs (Bc-sRNAs) can silence Arabidopsis and tomato genes involved in immunity. These Bc-sRNAs hijack the host RNA interference (RNAi) machinery by binding to Arabidopsis Argonaute 1 (AGO1) and selectively silencing host immunity genes. The Arabidopsis ago1 mutant exhibits reduced susceptibility to B. cinerea, and the B. cinerea dcl1 dcl2 double mutant that can no longer produce these Bc-sRNAs displays reduced pathogenicity on Arabidopsis and tomato. Thus, this fungal pathogen transfers "virulent" sRNA effectors into host plant cells to suppress host immunity and achieve infection, which demonstrates a naturally occurring cross-kingdom RNAi as an advanced virulence mechanism.
URI: http://dx.doi.org/10.1126/science.1239705
http://hdl.handle.net/11536/22682
ISSN: 0036-8075
DOI: 10.1126/science.1239705
期刊: SCIENCE
Volume: 342
Issue: 6154
起始頁: 118
結束頁: 123
Appears in Collections:Articles