標題: Non-metallic nanomaterials in cancer theranostics: a review of silica- and carbon-based drug delivery systems
作者: Chen, Yu-Cheng
Huang, Xin-Chun
Luo, Yun-Ling
Chang, Yung-Chen
Hsieh, You-Zung
Hsu, Hsin-Yun
應用化學系
應用化學系分子科學碩博班
Department of Applied Chemistry
Institute of Molecular science
關鍵字: theranostics;mesoporous silica nanoparticles;carbon-based nanomaterials;drug delivery systems
公開日期: 1-八月-2013
摘要: The rapid development in nanomaterials has brought great opportunities to cancer theranostics, which aims to combine diagnostics and therapy for cancer treatment and thereby improve the healthcare of patients. In this review we focus on the recent progress of several cancer theranostic strategies using mesoporous silica nanoparticles and carbon-based nanomaterials. Silicon and carbon are both group IV elements; they have been the most abundant and significant non-metallic substances in human life. Their intrinsic physical/chemical properties are of critical importance in the fabrication of multifunctional drug delivery systems. Responsive nanocarriers constructed using these nanomaterials have been promising in cancer-specific theranostics during the past decade. In all cases, either a controlled texture or the chemical functionalization is coupled with adaptive properties, such as pH-, light-, redox- and magnetic field-triggered responses. Several studies in cells and mice models have implied their underlying therapeutic efficacy; however, detailed and long-term in vivo clinical evaluations are certainly required to make these bench-made materials compatible in real bedside circumstances.
URI: http://dx.doi.org/10.1088/1468-6996/14/4/044407
http://hdl.handle.net/11536/22585
ISSN: 1468-6996
DOI: 10.1088/1468-6996/14/4/044407
期刊: SCIENCE AND TECHNOLOGY OF ADVANCED MATERIALS
Volume: 14
Issue: 4
結束頁: 
顯示於類別:期刊論文


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  1. 000323882000010.pdf