Title: A N-(2-Aminophenyl)-5-(dimethylamino)-1-naphthalenesulfonic Amide (Ds-DAB) Based Fluorescent Chemosensor for Peroxynitrite
Authors: Lin, Ku-Kuei
Wu, Shou-Cheng
Hsu, Kuang-Mei
Hung, Chen-Hsiung
Liaw, Wen-Feng
Wang, Yun-Ming
Department of Biological Science and Technology
Issue Date: 16-Aug-2013
Abstract: A dansyl derivative (Ds-DAB) was prepared and used as a fluorescent probe for peroxynitrite (ONOO-) detection. The results showed that the addition of peroxynitrite to the aqueous solution of Ds-DAB would result in obvious fluorescence enhancement. This probe is highly specific for peroxynitrite in aqueous solution, avoiding interference from other reactive oxygen species (ROS) and nitrogen species (RNS). The advantages of high selectivity, fast reaction rate, and peroxynitrite bioimaging render Ds-DAB suitable for peroxynitrite detection.
URI: http://dx.doi.org/10.1021/ol401932p
ISSN: 1523-7060
DOI: 10.1021/ol401932p
Volume: 15
Issue: 16
Begin Page: 4242
End Page: 4245
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