標題: Biomedical applications and colloidal properties of amphiphilically modified chitosan hybrids
作者: Larsson, Mikael
Huang, Wei-Chen
Hsiao, Meng-Hsuan
Wang, Yen-Jen
Nyden, Magnus
Chiou, Shih-Hwa
Liu, Dean-Mo
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Amphiphilic modified chitosan;Colloidal properties;Biomedical applications
公開日期: 1-Sep-2013
摘要: Chitosan is among the most abundant biopolymers on earth and has been either used or exhibited potential in a wide variety of industrial and biomedical applications. With the advancement of materials technologies, chitosan has been chemically modified to self-assemble into nanoarchitectures that are usable in advanced biomedical applications, such as drug nanocarriers, macroscopic injectables, tissue-engineering scaffolds, and nanoimaging agents. Colloidal amphiphilically modified chitosan (AMC) is a relatively recent material receiving increased attention with numerous publications addressing the medical advantages of specific systems. To date, many reviews have focused on the synthesis and biomedical properties of chitosan-based biomaterials, but a comprehensive study focusing on the colloidal properties of AMC in relation to biomedical performance appears to be lacking. This review provides a survey of the field, critically reviewing the colloidal properties and biomedical performance of AMC systems, such as nanoparticle drug delivery systems and macroscopic medical devices. Finally, the future development, market potential, and clinical implications of these promising colloidal-structured biomaterials are summarised. (C) 2013 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.progpolymsci.2013.06.009
http://hdl.handle.net/11536/22530
ISSN: 0079-6700
DOI: 10.1016/j.progpolymsci.2013.06.009
期刊: PROGRESS IN POLYMER SCIENCE
Volume: 38
Issue: 9
起始頁: 1307
結束頁: 1328
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