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dc.contributor.authorKandiah, Mathivathanien_US
dc.contributor.authorUrban, Pawel L.en_US
dc.date.accessioned2014-12-08T15:31:44Z-
dc.date.available2014-12-08T15:31:44Z-
dc.date.issued2013en_US
dc.identifier.issn0306-0012en_US
dc.identifier.urihttp://hdl.handle.net/11536/22459-
dc.identifier.urihttp://dx.doi.org/10.1039/c3cs35389cen_US
dc.description.abstractUltrasensitive mass spectrometric analysis of organic molecules is important for various branches of chemistry, and other fields including physics, earth and environmental sciences, archaeology, biomedicine, and materials science. It finds applications - as an enabling tool - in systems biology, biological imaging, clinical analysis, and forensics. Although there are a number of technical obstacles associated with the analysis of samples by mass spectrometry at ultratrace level (for example analyte losses during sample preparation, insufficient sensitivity, ion suppression), several noteworthy developments have been made over the years. They include: sensitive ion sources, loss-free interfaces, ion optics components, efficient mass analyzers and detectors, as well as "smart'' sample preparation strategies. Some of the mass spectrometric methods published to date can achieve sensitivity which is by several orders of magnitude higher than that of alternative approaches. Femto- and attomole level limits of detection are nowadays common, while zepto- and yoctomole level limits of detection have also been reported. We envision that the ultrasensitive mass spectrometric assays will soon contribute to new discoveries in bioscience and other areas.en_US
dc.language.isoen_USen_US
dc.titleAdvances in ultrasensitive mass spectrometry of organic moleculesen_US
dc.typeReviewen_US
dc.identifier.doi10.1039/c3cs35389cen_US
dc.identifier.journalCHEMICAL SOCIETY REVIEWSen_US
dc.citation.volume42en_US
dc.citation.issue12en_US
dc.citation.spage5299en_US
dc.citation.epage5322en_US
dc.contributor.department應用化學系zh_TW
dc.contributor.department應用化學系分子科學碩博班zh_TW
dc.contributor.departmentDepartment of Applied Chemistryen_US
dc.contributor.departmentInstitute of Molecular scienceen_US
dc.identifier.wosnumberWOS:000319527400029-
dc.citation.woscount9-
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