標題: Synthesis of acylguanidine zanamivir derivatives as neuraminidase inhibitors and the evaluation of their bio-activities
作者: Lin, Chien-Hung
Chang, Tsung-Che
Das, Anindya
Fang, Ming-Yu
Hung, Hui-Chen
Hsu, Kai-Cheng
Yang, Jinn-Moon
von Itzstein, Mark
Mong, Kwok Kong T.
Hsu, Tsu-An
Lin, Chun-Cheng
生物科技學系
應用化學系
Department of Biological Science and Technology
Department of Applied Chemistry
公開日期: 2013
摘要: A series of acylguanidine-modified zanamivir analogs were synthesized and their inhibitory activities against the NAs of avian influenza viruses (H1N1 and H3N2) were evaluated. In particular, zanamivir derivative 3j, with a hydrophobic naphthalene substituent, exhibits the best inhibitory activity against group-1 NA with an IC50 of 20 nM.
URI: http://hdl.handle.net/11536/22456
http://dx.doi.org/10.1039/c3ob40624e
ISSN: 1477-0520
DOI: 10.1039/c3ob40624e
期刊: ORGANIC & BIOMOLECULAR CHEMISTRY
Volume: 11
Issue: 24
起始頁: 3943
結束頁: 3948
顯示於類別:期刊論文