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dc.contributor.authorCheng, Kun-Shanen_US
dc.contributor.authorLiao, Yan-Chiouen_US
dc.contributor.authorChen, Mu-Yuanen_US
dc.contributor.authorKuan, Tang-Chingen_US
dc.contributor.authorHong, Yi-Hanen_US
dc.contributor.authorKo, Lien_US
dc.contributor.authorHsieh, Wen-Yehen_US
dc.contributor.authorWu, Chien-Liangen_US
dc.contributor.authorChen, Ming-Renen_US
dc.contributor.authorLin, Chih-Shengen_US
dc.date.accessioned2014-12-08T15:31:43Z-
dc.date.available2014-12-08T15:31:43Z-
dc.date.issued2013en_US
dc.identifier.issn1449-2288en_US
dc.identifier.urihttp://hdl.handle.net/11536/22444-
dc.identifier.urihttp://dx.doi.org/10.7150/ijbs.6398en_US
dc.description.abstractVentricular septal defect (VSD) is the most common form of congenital heart diseases. Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases involved in causal cardiac tissue remodeling. We studied the changes of circulating MMP-2 and MMP-9 activities in the patients with VSD severity and closure. There were 96 children with perimembranous VSD enrolled in this study. We assigned the patients into three groups according to the ratio of VSD diameter/diameter of aortic root (Ao). They were classified as below: Trivial (VSD/Ao ratio <= 0.2), Small (0.2 < VSD/Ao <= 0.3) and Median (0.3 < VSD/Ao) group. Plasma MMP-2 and MMP-9 activities were assayed by gelatin zymography. There was a significant higher MMP-2 activity in the VSD (Trivial, Small and Median) groups compared with that in Control group. The plasma MMP-9 activity showed a similar trend as the findings in MMP-2 activity. After one year follow-up, a significant difference in the MMP-9 activity was found between VSD spontaneous closure and non-closure groups. In conclusion, a positive trend between the severity of VSD and activities of MMP-2 and MMP-9 was found. Our data imply that MMP-2 and MMP-9 activities may play a role in the pathogenesis of VSD.en_US
dc.language.isoen_USen_US
dc.subjectMatrix metalloproteinase-2en_US
dc.subjectMatrix metalloproteinase-9en_US
dc.subjectTissue inhibitor of metalloproteinase-3en_US
dc.subjectVentricular septal defecten_US
dc.titleCirculating Matrix Metalloproteinase-2 and-9 Enzyme Activities in the Children with Ventricular Septal Defecten_US
dc.typeArticleen_US
dc.identifier.doi10.7150/ijbs.6398en_US
dc.identifier.journalINTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCESen_US
dc.citation.volume9en_US
dc.citation.issue6en_US
dc.citation.spage557en_US
dc.citation.epage563en_US
dc.contributor.department生物科技學系zh_TW
dc.contributor.departmentDepartment of Biological Science and Technologyen_US
dc.identifier.wosnumberWOS:000321284800004-
dc.citation.woscount1-
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