標題: A concise synthesis of 2-(2-aminothiophene)-benzimidazoles by one-pot multicomponent reaction
作者: Chen, Li-Hsun
Chuang, Ying-Sheng
Narhe, Bharat D.
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
公開日期: 2013
摘要: A one-pot synthesis of 2-aminothiophene linked benzimidazoles was achieved by utilizing 2-cyanomethyl benzimidazoles in a modified Gewald multicomponent reaction. The synthetic strategy of the reaction involved treatment of 2-(cyanomethyl)-benzimdazole with aldehydes containing an active methylene group and sulfur powder under refluxing conditions. The multicomponent reaction proceeded via Knoevenagel condensation of 2-(cyanomethyl)-benzimdazole with aldehyde to generate an alpha,beta-unsaturated nitrile followed by cyclization with molecular sulfur under basic conditions to give biologically relevant 2-(2-aminothiophene)-benzimidazoles in good yields.
URI: http://hdl.handle.net/11536/22423
http://dx.doi.org/10.1039/c3ra41545g
ISSN: 2046-2069
DOI: 10.1039/c3ra41545g
期刊: RSC ADVANCES
Volume: 3
Issue: 33
起始頁: 13934
結束頁: 13943
Appears in Collections:Articles


Files in This Item:

  1. 000322464500053.pdf