標題: A Telescoping Synthesis of Chimeric Polyheterocycles through a Piperidine-Mediated Multicomponent Reaction
作者: Lee, Chia-Hsin
Hsu, Wei-Shun
Chen, Chih-Hau
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Synthetic methods;Multicomponent reactions;Telescoping synthesis;Nitrogen heterocycles;Schiff bases
公開日期: 1-Apr-2013
摘要: A new piperidine-catalyzed Groebke-Bienayme-Blackburn (GBB) multicomponent reaction of 2-aminobenzimidazoles, methyl 2-formylbenzoate, and isocyanides has been explored. A facile and straightforward postmodification leads to isoquinolinone-embedded imidazo[1,2-a]benzimidazoles. Insight into a plausible mechanism is discussed and supported by X-ray crystal structure analysis.
URI: http://dx.doi.org/10.1002/ejoc.201201645
http://hdl.handle.net/11536/22395
ISSN: 1434-193X
DOI: 10.1002/ejoc.201201645
期刊: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume: 
Issue: 11
起始頁: 2201
結束頁: 2208
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