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dc.contributor.authorLin, Chih-Yungen_US
dc.contributor.authorChuang, Chao-Chunen_US
dc.contributor.authorHua, Tzu-Enen_US
dc.contributor.authorChen, Chun-Chaoen_US
dc.contributor.authorDickson, Barry J.en_US
dc.contributor.authorGreenspan, Ralph J.en_US
dc.contributor.authorChiang, Ann-Shynen_US
dc.date.accessioned2014-12-08T15:31:32Z-
dc.date.available2014-12-08T15:31:32Z-
dc.date.issued2013-05-01en_US
dc.identifier.issn2211-1247en_US
dc.identifier.urihttp://dx.doi.org/10.1016/j.celrep.2013.04.022en_US
dc.identifier.urihttp://hdl.handle.net/11536/22367-
dc.description.abstractHow the brain perceives sensory information and generates meaningful behavior depends critically on its underlying circuitry. The protocerebral bridge (PB) is a major part of the insect central complex (CX), a premotor center that may be analogous to the human basal ganglia. Here, by deconstructing hundreds of PB single neurons and reconstructing them into a common three-dimensional framework, we have constructed a comprehensive map of PB circuits with labeled polarity and predicted directions of information flow. Our analysis reveals a highly ordered information processing system that involves directed information flow among CX subunits through 194 distinct PB neuron types. Circuitry properties such as mirroring, convergence, divergence, tiling, reverberation, and parallel signal propagation were observed; their functional and evolutional significance is discussed. This layout of PB neuronal circuitry may provide guidelines for further investigations on transformation of sensory (e.g., visual) input into locomotor commands in fly brains.en_US
dc.language.isoen_USen_US
dc.titleA Comprehensive Wiring Diagram of the Protocerebral Bridge for Visual Information Processing in the Drosophila Brainen_US
dc.typeArticleen_US
dc.identifier.doi10.1016/j.celrep.2013.04.022en_US
dc.identifier.journalCELL REPORTSen_US
dc.citation.volume3en_US
dc.citation.issue5en_US
dc.citation.spage1739en_US
dc.citation.epage1753en_US
dc.contributor.department生物資訊及系統生物研究所zh_TW
dc.contributor.departmentInstitude of Bioinformatics and Systems Biologyen_US
dc.identifier.wosnumberWOS:000321899300041-
dc.citation.woscount9-
Appears in Collections:Articles


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