Title: Species distribution and drug susceptibilities of Candida isolates in TSARY 2010
Authors: Yang, Yun-Liang
Chen, Hui-Ting
Lin, Chih-Chao
Chu, Wen-Li
Lo, Hsiu-Jung
Department of Biological Science and Technology
Institute of Molecular Medicine and Bioengineering
Keywords: Antifungal;Candida species;Drug susceptibility
Issue Date: 1-Jun-2013
Abstract: Susceptibilities to antifungal drugs of 1083 Candida isolates collected in Taiwan Surveillance of Antimicrobial Resistance of Yeasts in 2010 were determined. There were 422 (39%) C albicans, 270 (24.9%) C tropicalis, 258 (23.8%) C glabrata, 87 (8%) C. parapsilosis, 18 (1.7%) C. krusei, and 28 (2.6%) of 13 other species. In the present study, we have applied species-specific clinical breakpoints for common species and epidemiological cutoff values for rare species. We found that majority of isolates were susceptible to tested drugs. A total of 15, 3, 2, and 0 isolates were not susceptible to fluconazole, voriconazole, amphotericin B, and anidulafungin, respectively. We found that three of the four fluconazole non-susceptible C albicans isolates were resistant to voriconazole. Hence, there is an issue of cross-resistance among azole-type drugs. (C) 2013 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.diagmicrobio.2013.03.003
ISSN: 0732-8893
DOI: 10.1016/j.diagmicrobio.2013.03.003
Volume: 76
Issue: 2
Begin Page: 182
End Page: 186
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