標題: Multicomponent Solvent-Free Synthesis Of Benzimidazolyl Imidazo[1,2-a]-pyridine Under Microwave Irradiation
作者: Maiti, Barnali
Chanda, Kaushik
Selvaraju, Manikandan
Tseng, Chih-Chung
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: microwave irradiation;benzimidazole-imidazo[1,2-a]pyridines;solvent-free;bis-heterocyclic skeletons;three-component reaction
公開日期: 1-六月-2013
摘要: A novel one-pot, three-component reaction employing variously substituted benzimidazole-linked amino pyridines, aldehydes, and isonitriles catalyzed by scandium(III) triflate under solvent-free conditions were accomplished. This new synthetic methodology facilitates the rapid generation of intricate molecular frameworks in three-dimensional fashion leading to benzinaidazole-imidazo [1,2-a] pyridines. This approach is envisioned as an environmentally benign process and a simple operation to the biological interesting compounds. The present synthetic sequence permits the introduction of three points of structural diversity to expand chemical space with high purity and excellent yields.
URI: http://dx.doi.org/10.1021/co400010y
http://hdl.handle.net/11536/22329
ISSN: 2156-8952
DOI: 10.1021/co400010y
期刊: ACS COMBINATORIAL SCIENCE
Volume: 15
Issue: 6
起始頁: 291
結束頁: 297
顯示於類別:期刊論文


文件中的檔案:

  1. 000320356100004.pdf