標題: VBM reveals brain volume differences between Parkinson's disease and essential tremor patients
作者: Lin, Ching-Hung
Chen, Chun-Ming
Lu, Ming-Kuei
Tsai, Chon-Haw
Chiou, Jin-Chern
Liao, Jan-Ray
Duann, Jeng-Ren
生醫電子轉譯研究中心
Biomedical Electronics Translational Research Center
關鍵字: voxel-based morphometry;Parkinson's disease;essential tremor;DARTEL VBM;basal ganglia;cerebellum;ventro-posterior-lateral thalamus;middle temporal gyrus
公開日期: 14-六月-2013
摘要: Symptoms of essential tremor (ET) are similar to those of Parkinsons disease (PD) during their initial stages. Presently, there are few stable biomarkers available on a neuroanatomical level for distinguishing between these two diseases. However, few investigations have directly compared the changes in brain volume and assessed the compensatory effects of a change in the parts of the brain associated with PD and with ET. To determine the compensatory and/or degenerative anatomical changes in the brains of PD and ET patients, the present study tested, via two voxel-based morphometry (VBM) approaches (Basic vs. DARTEL VBM processing), the anatomical brain images of 10 PD and 10 ET patients, as well as of 13 age-matched normal controls, obtained through a 3T magnetic resonance scanner. These findings indicate that PD and ET caused specific patterns of brain volume alterations in the brains examined. In addition, our observations also revealed compensatory effects, or self-reorganization, occurring in the thalamus and the middle temporal gyrus in the PD and ET patients, due perhaps in part to the enhanced thalamocortical sensorimotor interaction and the head-eye position readjustment, respectively, in these PD and ET patients. Such a distinction may lend itself to use as a biomarker for differentiating between these two diseases.
URI: http://dx.doi.org/10.3389/fnhum.2013.00247
http://hdl.handle.net/11536/22295
ISSN: 1662-5161
DOI: 10.3389/fnhum.2013.00247
期刊: FRONTIERS IN HUMAN NEUROSCIENCE
Volume: 7
Issue: 
結束頁: 
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