標題: Synthesis of nanocarriers with remote magnetic drug release control and enhanced drug delivery for intracellular targeting of cancer cells
作者: Tung, W-L.
Hu, S-H.
Liu, D-M.
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: Magnetic nanoparticles;Controlled release;Drug delivery;Targeting;Cancer
公開日期: 1-七月-2011
摘要: Nanotherapeutic strategy is well recognized as the therapeutic approach of the future. Numerous reports have demonstrated the use of nanoparticulate drug carriers for the development of targeted nanotherapeutics by, for instance, incorporation of a moiety that specifically targets certain diseased cells. However, systematic investigation of this aspect has been inadequate, especially with regard to nanosystems with remotely controlled drug delivery. The authors previously designed a magnetic-responsive core-shell drug delivery nanosystem which proved to be technically feasible in vitro. In the present study, this nanosystem is modified for targeted delivery of an anticancer agent (encapsulated camptothecin (CPT)) to cancer cells overexpressing epithelial growth factor receptor (EGFR) with accurate intracellular drug release. The endocytosis of the nanocarriers by cancer cells, the pathway of cellular uptake and the subsequent intracellular controlled drug delivery were systematically investigated. It was found that the modified nanocarriers showed reasonably high drug load efficiency for CPT and a high uptake rate by cancer cells overexpressing EGFR through clathrin-mediated endocytosis. The intracellular release of the CPT molecules via an external magnetic stimulus proved to be technically successful and ensured much higher therapeutic efficacy than that obtained with the free drug. This study employs multiple functions for nanotherapeutic treatment of specific target cells, i.e. cell-specific targeting, controlled cellular endocytosis and magnetic-responsive intracellular drug release. (C) 2011 Acta Materialia Inc. Published by Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.actbio.2011.03.021
http://hdl.handle.net/11536/22030
ISSN: 1742-7061
DOI: 10.1016/j.actbio.2011.03.021
期刊: ACTA BIOMATERIALIA
Volume: 7
Issue: 7
起始頁: 2873
結束頁: 2882
顯示於類別:期刊論文


文件中的檔案:

  1. 000292226000012.pdf