標題: Divergent Synthesis of Unsymmetrical Annulated Biheterocyclic Compound Libraries: Benzimidazole Linked Indolo-benzodiazepines/quinoxaline
作者: Chen, Li-Hsun
Chang, Chia-Mao
Salunke, Deepak B.
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: indolo-benzodiazepines/quinoxalines;Pictet-Spengler;diversity-oriented synthesis;PEG
公開日期: 1-Jul-2011
摘要: Diversity-oriented synthesis of novel benzimidazole linked indolo-benzodiazepine/quinoxaline ring systems using poly(ethylene glycol) as soluble polymer support is described. Corrunercially available 4-fluoro-3-nitrobenzoic acid and indoline were utilized for the construction of these annulated biheterocyclic compound libraries having multiple privileged structures with three-point structural diversity. A reagent based diversification approach coupled with the Pictet-Spengler-type condensation was used to construct the tetracydic indolo-benzodiazepines/quinoxalines on substituted benzimidazoles.
URI: http://dx.doi.org/10.1021/co200022u
http://hdl.handle.net/11536/21969
ISSN: 2156-8952
DOI: 10.1021/co200022u
期刊: ACS COMBINATORIAL SCIENCE
Volume: 13
Issue: 4
起始頁: 391
結束頁: 398
Appears in Collections:Articles


Files in This Item:

  1. 000292617500007.pdf