Title: Increased risk of deep neck infection among HIV-infected patients in the era of highly active antiretroviral therapy-a population-based follow-up study
Authors: Liu, Ching-Feng
Weng, Shih-Feng
Lin, Yung-Song
Lin, Chih-Sheng
Lien, Ching-Feng
Wang, Jhi-Joung
Department of Biological Science and Technology
Keywords: Deep neck infection;HIV;Highly active antiretroviral therapy
Issue Date: 22-Apr-2013
Abstract: Background: Deep neck infections (DNIs) in HIV-infected patients often produce severe complications, even death. Data on the incidence rates and risks of DNI among HIV-infected patients are scarce, particularly with the widespread use of highly active antiretroviral therapy (HAART). We evaluated the incidence rates and risks for DNI among HIV-infected patients and observed the long-term trends. Methods: A total of 9888 new HIV-infected patients diagnosed in 2001-2007 were included and matched with 49440 randomly selected subjects. The HIV-infected subjects were offered free access to HAART. All subjects were traced until December 2009. A Kaplan-Meier analysis generated the cumulative DNI incidence rate. The adjusted hazard ratio was computed using Cox proportional hazard regressions. Results: From the HIV-infected and comparison cohorts, 222 individuals (57.01 cases per 10000 person-years) and 735 individuals (35.54 cases per 10000 person-years) developed DNI, respectively. The log rank test indicated that patients with HIV had a significantly higher 8-year incidence rate of DNI than the control group (P < 0.0001). The adjusted hazard ratio for developing DNI after an HIV attack during the mean 3.94 years follow-up period was 1.59. The incidence rate and relative risk of DNI were 74.58 (per 10000 person-years) and 2.05 (P < 0.0001). Both figures were highest in the first follow-up year and decreased year-by-year thereafter. Conclusion: The risk of developing DNI is significantly elevated among HIV-infected patients, even with free access to HAART. Additional research is needed to examine the role of HAART in reducing the risk.
URI: http://dx.doi.org/10.1186/1471-2334-13-183
ISSN: 1471-2334
DOI: 10.1186/1471-2334-13-183
Volume: 13
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