Title: The zona incerta modulates spontaneous spike-wave discharges in the rat
Authors: Shaw, Fu-Zen
Liao, Yi-Fang
Chen, Ruei-Feng
Huang, Yu-Hsing
Lin, Rick C. S.
D Link NCTU Joint Res Ctr
Keywords: zona incerta;absence seizure;spike-wave discharge;tremor;deep brain stimulation
Issue Date: 1-May-2013
Abstract: The contribution of the zona incerta (ZI) of the thalamus on spike-wave discharges (SWDs) was investigated. Chronic recordings of bilateral cortices, bilateral vibrissa muscle, and unilateral ZI were performed in Long-Evans rats to examine the functional role of SWDs. Rhythmic ZI activity appeared at the beginning of SWD and was accompanied by higher-oscillation frequencies and larger spike magnitudes. Bilateral lidocaine injections into the mystacial pads led to a decreased oscillation frequency of SWDs, but the phenomenon of ZI-related spike magnitude enhancement was preserved. Moreover, 800-Hz ZI microstimulation terminates most of the SWDs and whisker twitching (WT; >80%). In contrast, 200-Hz ZI microstimulation selectively stops WTs but not SWDs. Stimulation of the thalamic ventroposteriomedial nucleus showed no obvious effect on terminating SWDs. A unilateral ZI lesion resulted in a significant reduction of 7- to 12-Hz power of both the ipsilateral cortical and contralateral vibrissae muscle activities during SWDs. Intraincertal microinfusion of muscimol showed a significant inhibition on SWDs. Our present data suggest that the ZI actively modulates the SWD magnitude and WT behavior.
URI: http://dx.doi.org/10.1152/jn.00750.2011
ISSN: 0022-3077
DOI: 10.1152/jn.00750.2011
Volume: 109
Issue: 10
Begin Page: 2505
End Page: 2516
Appears in Collections:Articles