標題: Label-Free Electrical Detection of DNA Hybridization on Graphene using Hall Effect Measurements: Revisiting the Sensing Mechanism
作者: Lin, Cheng-Te
Phan Thi Kim Loan
Chen, Tzu-Yin
Liu, Keng-Ku
Chen, Chang-Hsiao
Wei, Kung-Hwa
Li, Lain-Jong
材料科學與工程學系
Department of Materials Science and Engineering
關鍵字: label-free detection;Hall effect measurements;graphene;liquid-gated transistors;DNA sensors
公開日期: 13-五月-2013
摘要: There is broad interest in using graphene or graphene oxide sheets as a transducer for label-free and selective electrical detection of biomolecules such as DNA. However, it is still not well explored how the DNA molecules interact with and influence the properties of graphene during the detection. Here, Hall effect measurements based on the Van der Pauw method are used to perform single-base sequence selective detection of DNA on graphene sheets, which are prepared by chemical vapor deposition. The sheet resistance increases and the mobility decreases with the addition of either complementary or one-base mismatched DNA to the graphene device. The hole carrier concentration of the graphene devices increases significantly with the addition of complementary DNA but it is less affected by the one-base mismatched DNA. It is concluded that the increase in hole carrier density, indicating p-doping to graphene, is better correlated with the DNA hybridization compared to the commonly used parameters such as conductivity change. The different electrical observations of p-doping from Hall effect measurements and n-doping from electrolyte-gated transistors can be explained by the characteristic morphology of partially hybridized DNA on graphene and the mismatch between DNA chain length and Debye length in electrolytes.
URI: http://dx.doi.org/10.1002/adfm.201202672
http://hdl.handle.net/11536/21879
ISSN: 1616-301X
DOI: 10.1002/adfm.201202672
期刊: ADVANCED FUNCTIONAL MATERIALS
Volume: 23
Issue: 18
起始頁: 2301
結束頁: 2307
顯示於類別:期刊論文


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  1. 000318502700013.pdf