標題: Time-resolved mass spectrometry
作者: Chen, Yu-Chie
Urban, Pawel L.
應用化學系
Department of Applied Chemistry
關鍵字: Biochemical dynamics;Chemical reaction;Fast process;Kinetic measurement;Mass spectrometry;Reaction intermediate;Reaction monitoring;Structural determination;Temporal resolution;Time-resolved mass spectrometry
公開日期: 1-Mar-2013
摘要: Mass spectrometry (MS) offers advantages over conventional spectroscopic assays because it enables structural determination of reactants while preserving temporal resolution. The ability to detect short-lived reaction intermediates or labile metabolites makes time-resolved MS (TRMS) measurements an enabling tool for studies of chemical reactions, chemical kinetics and biochemical dynamics. High temporal resolution requires careful optimization of the interface, which would enable quenching of the chemical process, ionization and rapid transfer of the analytes into the mass analyzer. We review recent advances in TRMS, and outline the prospects for future developments and applications. (c) 2013 Elsevier Ltd. All rights reserved.
URI: http://dx.doi.org/10.1016/j.trac.2012.11.010
http://hdl.handle.net/11536/21743
ISSN: 0165-9936
DOI: 10.1016/j.trac.2012.11.010
期刊: TRAC-TRENDS IN ANALYTICAL CHEMISTRY
Volume: 44
Issue: 
起始頁: 106
結束頁: 120
Appears in Collections:Articles


Files in This Item:

  1. 000317148800018.pdf