標題: Effects of Freshwater Clam Extract Supplementation on Time to Exhaustion, Muscle Damage, Pro/Anti-Inflammatory Cytokines, and Liver Injury in Rats after Exhaustive Exercise
作者: Huang, Kuo-Chin
Wu, Wen-Tien
Yang, Fwu-Lin
Chiu, Yi-Han
Peng, Tai-Chu
Hsu, Bang-Gee
Liao, Kuang-Wen
Lee, Ru-Ping
生物科技學系
Department of Biological Science and Technology
關鍵字: Corbicula fluminea;anti-inflammatory;endurance performance;blood glucose
公開日期: 1-Apr-2013
摘要: The potent anti-inflammatory activities and tissue-protective effects of freshwater clams (Corbicula fluminea) have been well reported. The aim of this study was to determine the effects of freshwater clam extract (FCE) supplementation on time to exhaustion, muscle damage, pro-and anti-inflammatory cytokines, and liver injury in rats after exhaustive exercise. Thirty-two rats were divided into four groups: sedentary control (SC); SC group with FCE supplementation (SC+FCE); exhaustive exercise (E); and E group with FCE supplementation (E+FCE). The SC+FCE and E+FCE groups were treated with gavage administration of 20 mg/kg for seven consecutive days. Blood samples were collected for the evaluation of biochemical parameters. The cytokine levels of TNF-alpha and IL-10 were also examined. Twenty-four hours after exhaustive exercise, the rat livers were removed for H & E staining. The FCE supplementation could extend the time to exhaustion in exercised rats. The levels of CPK, LDH, AST, ALT, lactate, TNF-alpha and H & E stains of the liver injury were significantly decreased in the E+FCE group, but the blood glucose and IL-10 were significantly higher in comparison with the E group. This study suggests that FCE supplementation may improve endurance performance and reduce exercise-induced muscle damage, inflammatory stress and liver injury.
URI: http://dx.doi.org/10.3390/molecules18043825
http://hdl.handle.net/11536/21685
ISSN: 1420-3049
DOI: 10.3390/molecules18043825
期刊: MOLECULES
Volume: 18
Issue: 4
起始頁: 3825
結束頁: 3838
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