標題: Wireless near-infrared spectroscopy system for determining brain hemoglobin levels in laboratory animals
作者: Kuo, Jinn-Rung
Chang, Ming-Hsien
Wang, Che-Chuan
Chio, Chung-Ching
Wang, Jhi-Joung
Lin, Bor-Shyh
影像與生醫光電研究所
Institute of Imaging and Biomedical Photonics
關鍵字: Traumatic brain injury;Near-infrared spectroscopy;Oxyhemoglobin;Deoxyhemoglobin;Total hemoglobin;Triphenyltetrazolium chloride
公開日期: 15-四月-2013
摘要: Traumatic brain injury (TBI) is usually caused by brain shaking or impact. It can affect normal brain function and may even lead to disability or death. However, there are very few studies on the associated physiologic changes in humans or animals. In this study, a non-invasive, wireless multi-channel near-infrared spectroscopy (NIRS) was developed to continuously monitor the concentration change of oxyhemoglobin (HbO(2)), deoxyhemoglobin (HbR), and total hemoglobin (HbT) to elucidate changes in the physiological state of the brain during and after different strength impaction. The triphenyltetrazolium chloride (TTC) staining was also used to monitor changes of infarction volume after different strength impaction. The results indicated that the concentration changes of HbO(2) and HbT, and the changes of infarction volumes were significantly related to the impact strength. In conclusion, the status of TBI can be clinically evaluated by detecting HbO(2) and HbT changes. The system proposed here is stable, accurate, non-invasive, and mostly important wireless which can easily be used for TBI study. (C) 2013 Elsevier B.V. All rights reserved.
URI: http://dx.doi.org/10.1016/j.jneumeth.2013.01.025
http://hdl.handle.net/11536/21669
ISSN: 0165-0270
DOI: 10.1016/j.jneumeth.2013.01.025
期刊: JOURNAL OF NEUROSCIENCE METHODS
Volume: 214
Issue: 2
起始頁: 204
結束頁: 209
顯示於類別:期刊論文


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  1. 000317257100012.pdf