標題: One pot three component reaction for the rapid synthesis of pyrrolo[1,2-a]benzimidazoles
作者: Hsu, Wei-Shun
Paike, Vijaykumar
Sun, Chung-Ming
應用化學系
Department of Applied Chemistry
關鍵字: Pyrrolo[1, 2-a]benzimidazole;Microwave chemistry;Soluble supported synthesis;Ionic liquid;One-pot three component;Multicomponent reaction (MCR)
公開日期: 1-五月-2013
摘要: An efficient strategy for the synthesis of pyrrolo[1,2-]-benzimidazole (PBI) linked to an ionic liquid (ILs) as a soluble support under microwave irradiation was explored. The key intermediate benzimidazoles were synthesized via N-acylation followed by cyclodehydration of IL-supported methyl-3-amino-4-(isobutylamino) benzoate. The synthesis of the IL-bound PBI was performed by one-pot three-component condensation under microwave dielectric heating, which involved a Knoevenagel condensation and a [4+1]-cycloaddition reaction. The reaction was monitored directly by means of H NMR. All final products were obtained in good yield and high purity after precipitation.
URI: http://dx.doi.org/10.1007/s11030-013-9433-2
http://hdl.handle.net/11536/21650
ISSN: 1381-1991
DOI: 10.1007/s11030-013-9433-2
期刊: MOLECULAR DIVERSITY
Volume: 17
Issue: 2
起始頁: 285
結束頁: 294
顯示於類別:期刊論文


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