標題: Very small photoluminescent gold nanoparticles for multimodality biomedical imaging
作者: Lai, Sheng-Feng
Chien, Chia-Chi
Chen, Wen-Chang
Chen, Hsiang-Hsin
Chen, Yi-Yun
Wang, Cheng-Liang
Hwu, Y.
Yang, C. S.
Chen, C. Y.
Liang, K. S.
Petibois, Cyril
Tan, Hui-Ru
Tok, Eng-Soon
Margaritondo, G.
電子物理學系
Department of Electrophysics
關鍵字: Photoluminescence;Au nanoparticles;X-ray imaging;Cellular uptake;Radiation synthesis;Cytotoxicity;Tumor development
公開日期: 1-May-2013
摘要: An original synthesis method based on X-ray irradiation produced gold nanoparticles (AuNPs) with two important properties for biomedical research: intense visible photoluminescence and very high accumulation in cancer cells. The nanoparticles, coated with MUA (11-mercaptoundecanoid acid), are very small (1.4 nm diameter); the above two properties are not present for even slightly larger sizes. The small MUA-AuNPs are non-cytotoxic (except for very high concentrations) and do not interfere with cancer cell proliferation. Multimodality imaging using visible light fluorescence and X-ray microscopy is demonstrated by tracing the nanoparticle-loaded tumor cells. (C) 2012 Elsevier Inc. All rights reserved.
URI: http://dx.doi.org/10.1016/j.biotechadv.2012.05.005
http://hdl.handle.net/11536/21502
ISSN: 0734-9750
DOI: 10.1016/j.biotechadv.2012.05.005
期刊: BIOTECHNOLOGY ADVANCES
Volume: 31
Issue: 3
起始頁: 362
結束頁: 368
Appears in Collections:Conferences Paper


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