標題: Synthesis of L-hexoses and their related biomolecules
作者: Zulueta, Medel Manuel L.
Zhong, Yong-Qing
Hung, Shang-Cheng
應用化學系
Department of Applied Chemistry
公開日期: 2013
摘要: Carbohydrates either conjugated or as free entities are major players in numerous biological processes. The desire to comprehend the nature of their functions and further develop therapeutic and diagnostic applications has fuelled the recent upsurge in the glycoscience field. Mainly accessed through chemical synthesis, homogeneous and well-defined sugar constructs are on high demand for structure-activity evaluation. Although the D-sugars, particularly the D-hexoses, have dominated the carbohydrate landscape, L-hexoses also attracted attention because they are known components of important polysaccharides, antibiotics, and other natural products. Nonetheless, the L-hexose-based materials needed for making building blocks for sugar assemblies are rare and are usually expensive if commercially available. Thus, intense efforts were focused on the development of innovative and reliable methods for the acquisition of L-hexoses and their derivatives. This review outlines several efficient and cost-effective routes for the chemical syntheses of L-hexoses, particularly focusing on approaches that utilize commercially abundant sugars as starting materials. A sampling of the applications of the generated L-hexoses in preparing biologically relevant compounds is also provided.
URI: http://hdl.handle.net/11536/21467
http://dx.doi.org/10.1039/c3cc37733d
ISSN: 1359-7345
DOI: 10.1039/c3cc37733d
期刊: CHEMICAL COMMUNICATIONS
Volume: 49
Issue: 32
起始頁: 3275
結束頁: 3287
Appears in Collections:Articles


Files in This Item:

  1. 000316693100001.pdf