標題: Electrospun Fibers as a Solid-State Real-Time Zinc Ion Sensor with High Sensitivity and Cell Medium Compatibility
作者: Syu, Jia-Hao
Cheng, Yi-Kai
Hong, Wun-Yan
Wang, Hsing-Ping
Lin, Yu-Chao
Meng, Hsin-Fei
Zan, Hsiao-Wen
Horng, Sheng-Fu
Chang, Gao-Fong
Hung, Chen-Hsiung
Chiu, Yu-Cheng
Chen, Wen-Chang
Tsai, May-Jywan
Cheng, Henrich
物理研究所
光電工程學系
Institute of Physics
Department of Photonics
關鍵字: electrospun fibers;zinc ion sensors;solid-state materials;real-time detection
公開日期: 25-Mar-2013
摘要: meso-2,6-Dichlorophenyltripyrrinone (TPN-Cl2), a probe molecule for zinc II ions, is dispersed in a polymer host. The red fluorescence peak at 620 nm appears when the molecule forms a complex with zinc at its center. TPN-Cl2 has a high selectivity for zinc II and tolerates many common metal ions present in the human body. The probe molecules are blended with a hydrogel polymer, poly(2-hydroxyethyl methacrylate) (poly HEMA), with 30 wt% dimethylformamide (DMF). The fiber structure with 1 m diameter is made by electrospinning in DMF solution of the probe and poly HEMA mixture. The fibrous film detects zinc ions with concentrations as low as 106 M in real-time both in water and in the commonly used cell culture liquid media Dulbecco's modified Eagle medium (DMEM) and fetal bovine serum (FBS), which contain many metal ions and proteins. The time-resolution is 5 min for 106 M and 1 min for 105 M. This sensitivity and response speed satisfy the requirements for non-invasive biomedical studies.
URI: http://dx.doi.org/10.1002/adfm.201201242
http://hdl.handle.net/11536/21373
ISSN: 1616-301X
DOI: 10.1002/adfm.201201242
期刊: ADVANCED FUNCTIONAL MATERIALS
Volume: 23
Issue: 12
起始頁: 1566
結束頁: 1574
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