Title: Growth of gold nanowires on flexible substrate for highly sensitive biosensing: detection of thrombin as an example
Authors: Chen, Yu-Liang
Lee, Chi-Young
Chiu, Hsin-Tien
Department of Applied Chemistry
Issue Date: 2013
Abstract: We demonstrated a facile fabrication of high density Au nanostructures including nanothorns (NTs), nanocorals (NCs), nanoslices (NSs), and nanowires (NWs) which were electrochemically grown on flexible plastic substrates of polyethylene terephthalate (PET). A thrombin-binding aptamer was immobilized on the surfaces of the Au nanostructures to form highly sensitive electrochemical impedance spectroscopic (EIS) biosensors for thrombin recognition. The binding of thrombin to the aptamer sequence was monitored by EIS in the presence of [Fe(CN)(6)]((aq))(3-/4-). The protein (1-50 pM) was detected linearly by the Au nanostructures. Among them, the Au NWs exhibited excellent thrombin detection performances. The biosensor provided high sensitivity, selectivity, and stability due to its high surface area.
URI: http://hdl.handle.net/11536/21285
ISSN: 2050-750X
DOI: 10.1039/c2tb00010e
Volume: 1
Issue: 2
Begin Page: 186
End Page: 193
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